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      • Human Primary Cells
        • Gastrointestinal Cell System

Human Small Intestine Epithelial Cells

Reference: P10756


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Data Sheet

Human Small Intestine Epithelial Cells (HSIEpiC) are derived from whole small intestines that have been dissociated into single cells and purified in culture. HSIEpiC are from a single donor and they are highly purified epithelial cells as determined by specific epithelial cell markers. Intestine epithelial cells play important functions in the maintenance of overall individual health. In addition to their primary roles in absorbing nutrients and in serving as a physical barrier between the outside world and the inside environment, intestine epithelial cells are crucial in maintaining homeostasis of the mammalian immune and endocrine system in the context of health and disease. A failing intestine epithelium can lead to various disorders such as hormonal imbalance, inflammatory bowel disease (IBD), weight gain, and diabetes. Thus insights into the mechanisms of and remedies for those disorders can be gained from in vitro systems offered by the availability of human intestine epithelial cells.


Features/Benefits


Human small intestines epithelial cells enable researchers to study the role of epithelium located within the three compartments of the small intestines; the duodenum, jejunum, and ileum. These cells are ideal for screening drug candidates for their intestinal absorption potential. Functionally, P10756 cells secrete glucagon-like peptide 1 (GLP1), an insulinotropic factor, in response to glucose, or to the combined effect of the anti-diabetic compound tolbutamide, a potassium channel blocker, and the elevation of intracellular cAMP level, induced by forskolin and IBMX. Since GLP1 may play an important role in obesity, P10756 cells may be a valuable tool for diabetes and weight control research.


Number of Cells

  • 5x105 cells / vial

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