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Innoprot

  • Innoprot
    • Productos
      • Human Primary Cells
        • Gastrointestinal Cell System

Human Colonic Microvascular Endothelial Cells

Reference: P10769


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Data Sheet

Human Colonic Microvascular Endothelial Cells (HCoMEC) provided by Innoprot are isolated by ScienCell Research Laboratories from human colonic tissue. HCoMEC are cryopreserved at passage one and delivered frozen.

Innoprot also offers optimized medium and reagents for the growth of Human Colonic MIcrovascular Endothelial Cells which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro HCoMEC culture.


Features/Benefits


The colorectum is a major organ for both malignant and nonmalignant diseases. Endothelial cells lining the microvasculature are known to play a critical “gatekeeper” role in the inflammatory process through their ability to recruit circulating immune cells into tissues and foci of inflammation. Studies show that intestinal microvascular endothelial cells exhibit a strong immune response to LPS challenge and play a critical regulatory role in gut inflammation. Pharmacological inhibition of NOS in activated intestinal microvascular endothelial cells resulted in a significant increase in leukocytes binding. Gene expression profile study reveals that intestinal endothelial cells express biotinidase, which is involved in biotin recycling. The in vitro culture of these cells enabled scientists to perform systematic analyses of the cytokine profiles with regard to mRNA expression and protein secretion, and to compare such data with cytokine profiles concomitantly displayed by other endothelial cells.


Number of Cells

  • 5x105 cells / vial

 

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