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Innoprot

  • Innoprot
    • Productos
      • Human Primary Cells
        • Gastrointestinal Cell System

Human Esophageal Microvascular Endothelial Cells

Reference: P10764


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Data Sheet

Human Esophageal Microvascular Endothelial Cells (HEMEC) provided by Innoprot are isolated by ScienCell Research Laboratories from human Esophageal Tissue. HEMEC are cryopreserved at passage one and delivered frozen.

Innoprot also offers optimized medium and reagents for the growth of Human Esophageal Microvascular Endothelial Cells which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro HEMEC culture.


Features/Benefits


Endothelial cells lining the microvasculature are known to play a critical “gatekeeper” role in the inflammatory process through their ability to recruit circulating immune cells into tissues and foci of inflammation. Studies show that esophageal microvascular endothelial cells exhibit a strong inflammatory immune response to LPS, cytokines, and pH exposure, thus playing a critical regulatory role in esophageal inflammation. When exposed to acidic pH, HEMEC express some proteins, such as VCAM-1, but not others, such as ICAM-1, which is speculated to selectively recruit leukocytes to the esophagus. This could play a role in the cellular response triggered by gastroesophageal reflux disease. In vitro cultures of HEMEC have enabled scientists to observe leukocyte binding, upregulation of cell adhesion molecules, and other cellular responses to LPS, cytokines and pH exposure that indicate that HEMECs are intrinsically different from lower gastrointestinal endothelial cells in regards to an inflammatory immune response



Number of Cells

  • 5x105 cells / vial

 

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