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Innoprot

  • Innoprot
    • Productos
      • Human Primary Cells
        • Skeletal Cell System

Human Nucleus Pulposus Cells

Reference: P10973


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Data Sheet

Human Nucleus Pulposus Cells (HNPC) provided by Innoprot are isolated from nucleus pulposus of human invertibral disc. HNPC are cryopreserved at primary or passage one culture and delivered frozen. HNPC are guaranteed to further expand for 15 population doublings in the conditions provided in the data sheet.

Innoprot also offers optimized medium and reagents for the growth of Human Nucleus Pulposus Cells which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro HNPC culture.


Features/Benefits


Nucleus pulposus is the jelly-like substance in the middle of the intervertebral disc. It functions to distribute hydraulic pressure in all directions within each disc under compressive loads. The nucleus pulposus consists of collagen fibrils, proteoglycan aggrecans and nucleus pulposus cells. The nucleus pulposus cells reside in an environment that has a limited vascular supply and generate energy through anaerobic glycolysis. The cells synthesize collagen II and X; express hypoxia-inducible factor-1; and secrete interleukins-1, -6, and -10 and granulocytemacrophage colony-stimulating factor in culture. Mechanical stress on nucleus pulposus cells promotes cell proliferation. The nucleus pulposus cell culture provides an in vitro model for the study of cellular and molecular events involved in disc degeneration, tissue engineering and cell therapy for spine disc disorders.


Number of Cells

  • 5x105 cells / vial
 

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