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  • Innoprot
    • Productos
      • Human Primary Cells
        • Skeletal Cell System

Annulus Fibrosus Cells

Reference: P10974

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Data Sheet

Human Annulus Fibrosus Cells (HAFC) provided by Innoprot are isolated from annulus fibrosus of human intervertibral disc. HAFC are cryopreserved at primary or passage one culture and delivered frozen. HAFC are guaranteed to further expand for 15 population doublings in the conditions provided in the data sheet.

Innoprot also offers optimized medium and reagents for the growth of Human Annulus Fibrosus Cells which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro HAFC culture.


Degeneration of the intervertebral disk is a major pathological process implicated in low back pain. The causes of low back pain have been suggested to involve genetic, environmental, and psychosocial factors. The annulus fibrosus makes up the peripheral portion of disk structure, composed of fibrocartilage and type I and II collagen. Cells of the intervertebral disc are influenced by both biophysical and mechanical factors in their local environment. The annulus fibrosus cells can be stimulated by interleukin 1 beta to produce factors implicated in local degradative and inflammatory processes. The human annulus firosus cell culture provides an in vitro model for the study of cellular and molecular events involved in disc degeneration, tissue engineering and cell therapy for spine disc disorders.

Number of Cells

  • 5x105 cells / vial

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