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Innoprot

  • Innoprot
    • Productos
      • Human Primary Cells
        • Hepatic Cell System

Human Hepatic Stellate Cells

Reference: P10653


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Data Sheet

Human Hepatic Stellate Cells (HHSteC) provided by Innoprot are isolated by ScienCell Research Laboratories from human liver. HHSteC are cryopreserved immediately after purification and delivered frozen. HHSteC are guaranteed to further expand for 15 population doublings in the conditions provided by ScienCell Research Laboratories.

Innoprot also offers optimized medium and reagents for the growth of Human Hepatic Stellate Cells which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro HSteC culture.

Features/Benefits


HSteC are intralobular connective tissue cells presenting myofibroblast-like or lipocyte phenotypes. They participate in the homeostasis of liver extracellular matrix, repair, regeneration, fibrosis and control retinol metabolism, storage and release. Following liver injury, HSteC transform into myofibroblast-like cells and are the major source of type I collagen in the fibrotic liver. Beyond these feature, HSteC have been implicated as regulators of hepatic microcirculation via cell contraction, and in disease states, in the pathogenesis of intrahepatic portal hypertension. Proliferation and migration of HSteC and expression of chemokines are involved in the pathogenesis of liver inflammation and fibrogenesis. HSteC possess voltage-activated calcium current, express the low affinity nerve growth factor receptor p75, and undergo apoptosis in response to nerve growth factor stimulation. Therefore, the new insight into the molecular regulation of HSteC activation will lead to therapeutic approaches in treatment of hepatic fibrosis in the future, and could lead to reduced morbidity and mortality in patients with chronic liver injury.

Number of Cells

  • 5x105 cells / vial

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