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Innoprot

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      • Human Primary Cells
        • Reproductive cell System

Human Leydig Cells

Reference: P10795


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Data Sheet

Human Leydig Cells have been isolated from human testis by Sciencell Research Laboratories. HLC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HLC are characterized by immunofluorescence with antibody specific to GATA-4 and CK-18. HLC are guaranteed to further expand for 5 population doublings under the conditions provided in the technical sheet; however, HLC are not recommended for expanding or long-term cultures due to limited expansion capacity.

Innoprot also offers optimized medium and reagents for the growth of Human Leydig Cells which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro HLC culture.


Features/Benefits


Leydig Cells (LC) are located in the interstitium of the testis near the seminiferous tubules. One of the main functions of LC is to produce testosterone after stimulation by pituitary luteinizing hormone. LC, through synthesis of testosterone, play a key role in mammalian sex determination by inducing differentiation of the Wolffian ducts into male reproductive organs. Additionally, LC produce insulin-like growth factor 3 which is required for scrotal descent of the testis. Recent studies have indicated that molecules such as cyclic nucleotide phosphodiesterases can modulate testosterone production in LC, suggesting that testosterone synthesis may be manipulated using pharmacological targeting. Cultured Human LC are a useful in vitro model to better understand testicular development and to develop treatments for male reproductive disorders.


Number of Cells

  • 5x105 cells / vial

 

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