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Innoprot

  • Innoprot
    • Productos
      • Animal Primary Cells
        • Hepatic Cell System

Mouse Hepatic Stellate Cells

Reference: P10623


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Data Sheet

Mouse Hepatic Stellate Cells (MHSteC) provided by Innoprot are isolated by Innoprot from Swiss mice. MHSteC are cryopreserved immediately after purification and delivered frozen (passage “0”). MHSteC is not recommend for expanding or long term cultures since these cells would differentiate to become fibroblat-like cells immediately after plating and they will not proliferate in culture.

Innoprot also offers optimized medium and reagents for the growth of Hepatic Stellate Cells which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro HSteC culture.


Features/Benefits


MHSteC are intralobular connective tissue cells presenting myofibroblast-like or lipocyte phenotypes. They participate in the homeostasis of liver extracellular matrix, repair, regeneration, fibrosis and control retinol metabolism, storage and release. Following liver injury, MHSteC transform into myofibroblast-like cells and are the major source of type I collagen in the fibrotic liver. Beyond these feature, MHSteC have been implicated as regulators of hepatic microcirculation via cell contraction, and in disease states, in the pathogenesis of intrahepatic portal hypertension. MHSteC possess voltage-activated calcium current, express the low affinity nerve growth factor receptor p75, and undergo apoptosis in response to nerve growth factor stimulation. Therefore, the new insight into the molecular regulation of MHSteC activation will lead to therapeutic approaches in treatment of hepatic fibrosis in the future, and could lead to reduced morbidity and mortality in patients with chronic liver injury.
 

Product Size

  • Cryopreserved vial: 5x105 cells / vial
  • T-25 Flask
  • 96-Well Plate
 


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