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  • Innoprot
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      • GPCR Cell Lines

HiTSeeker CHRM1 (Muscarinic Receptor 1)

Reference: P30104

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Data Sheet

Each vial of this product contains U2OS cells or HEK293 cells stably expressing human Muscarinic acetylcholine receptor M1 with no tag. We offer this cell line as a “stable cell line” but we are now also offering vials of division-arrested cells (DA cells) in order to perform a small number of assays. Each vial of these DA cells contains 2.5 million cells, an enough number of cells to perform a complete experiment in a 96 well-plate or 384 well-plate.

HiTSeeker M1 cell line has been designed to assay compounds or analyze their capability to modulate Muscarinic acetylcholine receptor M1. When the agonist binds to M1 a G protein is activated, which in turn, triggers a cellular response mediated by second messengers (e.g. Calcium).

This cell line has been validated measuring calcium increase in the cytosol. The high reproducibility of this assay allows monitoring M1 activation process in High Throughput Screening.

Materials Provided

  • P30104: 2 vials of 3 million stably transfected HEK293 Cells expressing CHRM1
  • P30104-DA: 1 vial with 2.5 million Division Arrested HEK293 Cells expressing CHRM1 (READY TO USE)
  • P30142: 2 vials of 3 million stably transfected U2OS Cells expressing CHRM1
  • P30142-DA: 1 vial with 2.5 million Division Arrested U2OS Cells expressing CHRM1 (READY TO USE)

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