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      • Immortalized Human Primary Cells

Immortalized Human Brain Microvascular Endothelial Cells

Reference: P10361-IM

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Data Sheet

HBMEC‐IM from Innoprot have been obtained immortalizing Human Primary Brain Microvascular Endothelial Cells with Lenti‐SV40 Lentivirus. Immortalized cells were controlled passaging side by side with the primary cells. Primary cells go into senescence after the 3rd passage while the SV40‐tranduced cells go beyond 30 passages.

Innoprot also offers optimized medium and reagents for the growth of Immortalized HBMEC which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro culture.

Features/Benefits

The Brain MEC are the major element of the blood-brain barrier and comprise the primary limitation to passage of substances, both soluble and cellular, from the blood into the brain. Brain MEC utilizes unique features that distinguish themselves from those of peripheral endothelial cells. Like peripheral endothelial cells, however, brain MEC express, or can be induced to express, cell adhesion molecules on their surface that regulate the extravasation of leukocytes into the brain. In view of the organ specificity of MEC, Brain MEC has been widely used for studying the molecular and cellular basis of blood-brain barrier.

Number of Cells

• 1x10⁶ cells / vial

 

Related Products/Services

• P60104: Endothelial Cell Medium
• P60305: Primary Cells Detach Kit
• P8248: Fibronectin
• CryoStor® CS10 - Cryopreservation Medium

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