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Innoprot

  • Innoprot
    • Productos
      • Stable Cell Lines
        • Immortalized Human Primary Cells

Immortalized Human Hepatic Sinusoidal Endothelial Cells

Reference: P10652-IM


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Data Sheet

HHSEC‐IM from Innoprot have been obtained immortalizing Human Primary Hepatic Sinusoidal Endothelial Cells with Lenti‐SV40 Lentivirus. Immortalized cells were controlled passaging side by side with the primary cells. Primary cells go into senescence after the 3rd passage while the SV40‐tranduced cells go beyond 30 passages.

Innoprot also offers optimized medium and reagents for the growth of Immortalized HHSEC which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro culture.


Features/Benefits


SEC are microvascular endothelial cells with a unique phenotype reminiscent of dendritic cells and a unique function as antigen-presenting cells for CD4+ T cells. Thus, SEC represent a new type of organ-resident "non-professional" antigen-presenting cell that appears to be involved in the local control of the immune response and the induction of immune tolerance in the liver. SEC express well-characterized surface receptors and differ morphologically and metabolically from large-vessel endothelia. It has reported that SEC are dynamic regulators of porosity that respond rapidly and locally to environmental zonal stimuli during liver regeneration. Due to its strategic position in the liver sinusoid, SEC dysfunction and structural alterations have far-reaching repercussions for the whole liver.


Number of Cells

  • 1x106 cells / vial

  

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