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GPCR Cell Lines

Innoprot has developed a proprietary technology for multiplexing GPCR functional assays in living cells using fluorescent reporter genes. This technology called Nomad Biosensors allows the measurement simultaneously
of the different signalling pathways associated to GPCR activation (β-arrestin recruitment, Ca2+, cAMP or DAG).

GPCR cell lines developed by Innoprot has been validated for HTS and compound profiling. Different parental cell lines, such as HEK293, CHO-K1 or U2OS have been used based on the receptor characteristics and functional assay selected.

The use of Nomad Biosensors in a HTS campaign reduces the time, costs and resources needed in more than a 50-70%. It is the unique way to identify biased ligands in a single assay, which may reduce on-target adverse effects or engender novel pharmacology.

Learn more about NOMAD Biosensors.

If you are interested in a customized development using this new technology, please contact us at innoprot@innoprot.com.

GPCR Nomad Cell Lines - References

You can find below the different GPCR cell lines developed by Innoprot, including our multiplex GPCR Nomad Cell Lines, stable cell lines expressing label-free GPCR and both beta arresting biosensor & calcium or cAMP biosensor.


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