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Innoprot

ALS Model - TDP-43 Stress Granules Assay

Data Sheet


Amyotrophic lateral sclerosis (ALS) is one of the most common degenerative disease of the motor neuron system.The TDP-43 pathology seems to be a dominant type of pathology across sporadic ALS types.
Innoprot has developed a novel fluorescence cell-based assay for High Content Screening that allows the quantification of pathological TDP43 globs into the nucleus and cytosol


Assay Details


Cells will be induced to express the TDP43-tGFP. After that, the cells will be incubated with the compounds to be tested during 24 hours using Arimoclomol at 10 uM as positive control. Then, the cells will be treated with 250 uM sodium arsenite. The TDP43-tGFP nuclear globs will be quantified using the BD Pathway HCS Reader and Attovision Compartimentalization Software.


Applications

 

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