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Oxidative Stress Assay

Data Sheet

The oxidative stress is an imbalance between the production of reactive oxygen strains and the capacity of the cell to remove them. The excess of these strains finally produce peroxides and free radicals that damage cell components and compromise the cell functions. In most of the cell toxicity cases the external compound which interact with the cells produces a redox imbalance that triggered apoptotic and necrotic signals. But the oxidative stress also is a common event in most of the degenerative disease such as Alzheimer disease, dementia, or cancer.

Assay Details

A specific probe called CM-H2DCFDA (Molecular probes) is used to evaluate the redox level  which in contact with the reactive oxygen strains produces a specific fluorescence and it is possible to evaluate the redox status in living cells*. The cells are incubated with tested compounds and the fluorescent signal respect to control is evaluated using the BD Pathway 855 High Content Bioimager.

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