DNA Damage Assay

DNA Damage Assay

Several processes or insults can induce damage on DNA; such as a cell death pathway activation or by the genotoxic activity of a compound; substances that makes them harmful to the genetic information contained in organisms. Genotoxins are the substances that have the property of genotoxicity. All new chemical entities in the drug discovery process…

Mitochondrial Integrity Assay

Mitochondria are cellular organelles regulating metabolism and cell death pathways. The membrane of the mitochondria is the key component to maintain the cell metabolism and homeostasis. Loss of membrane potential of mitochondria is the previous event of the cell dysfunction; a pathway directly related with the activation of death pathways via caspase 3 activation. Mitochondrial Integrity…

Caspase 3-7 Activity Assay

Caspase 3-7 Activity Assay

Apoptosis, or programmed cell death, is a normal component of the development and health of multicellular organisms. Caspase 3-7 Activity Assay from Innoprot quantifies the apoptotic level in living cells. Apoptosis evaluation study is a cellular assay to evaluate the activation level of the caspase 3 protein which is a key role component during apoptosis…

Oxidative Stress Assay

The oxidative stress is an imbalance between the production of reactive oxygen strains (ROS); and the capacity of the cell to remove them. The excess of these strains finally produce peroxides and free radicals that damage cell components and compromise the cell functions. Oxidative Stress Assay from Innoprot uses a specific probe (CM-H2DCFDA) to evaluate…