alpha1B adrenoreceptor assay

alpha1B adrenoceptor assay

alpha1B Adrenoceptor assay (ADRA1B) from Innoprot provides the analysis of both signalling pathways involving receptor activation; G protein by Calcium flux and β-arrestin recruitment using Nomad multiplex technology.

The alpha-1B adrenergic receptor (α1B adrenoceptor), also known as ADRA1B, is member of Alpha-1-adrenergic receptors (alpha-1-ARs) family. They activate mitogenic responses and regulate growth and proliferation of many cells. The primary transduction mechanism is mediated by Gq/G11 family transducers, so its activation response is easily measured by calcium flux.

Cell line used:ADRA1B Nomad Cell Line
Readout: Calcium Flux & β-arrestin recruitment
Agonist: Epinephrine
EC50 Agonist: 8.76 x 10-8 M for Calcium assay & 1.27 x 10-7 M for β-arrestin recruitment
  • Type of Assay: Cell based / Functional
  • Detection Method: Fluorimetry

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Cell Line Information

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