BB2 bombesin receptor Cell Line

BB2 Bombesin Receptor Assay from Innoprot allows the measurement of BB2 Bombesin receptor activation by Calcium concentration increase in the cytosol.

BB2 Bombesin Receptor, a.k.a. gastrin-releasing peptide receptor (GRPR), is a G protein-coupled receptor whose endogenous ligand is gastrin releasing peptide (GRP). It appears in the pancreas and also in the stomach, adrenal cortex and brain. Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems; including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. In CNS, Bombesin-like peptides induce satiety and play a role in thermoregulation and induce histamine-independent pruritus. It is also a potent mitogen for neoplastic tissues. BB2 Bombesin Receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate.

Cell line used: HiTSeeker BB2 Receptor Cell Line

Readout: Calcium Flux

Agonist: GRP

EC50 Agonist: 3.2 x 10-10 M for Calcium Flux

Type of Assay: Cel-based/Functional

Detection Method: Fluorimetry

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