Innoprot offers several Parkinson’s Disease in vitro models that address the disease through different associated cellular pathways; including parkin recruitment, MPP+ damage induction, or alpha-synuclein aggregation.

Parkin Mitochondrial Recruitment Assay

Parkin Mitochondrial Recruitment Assay

Parkin mitochondrial recruitment assay from Innoprot is based of localization changes of two fluorescent proteins; the Parkin fluorescent fusion polypeptide that changes its localization from the cytosol to the outer mitochondrial membrane (OMM); and the other fluorescent fusion polypeptide (MTS-tGFP), which binds directly to OMM, allowing the mitochondrial integrity analysis. Several compounds promote Parkin recruitment,…