CXCR2 Chemokine Receptor Internalization Assay from Innoprot allows to assay compounds, or analyze their capability to modulate CXCR2 receptor activation and the following redistribution process inside the cells. When a ligand binds to the CXCR2, it activates a G protein, which internalizes in big and high intensity vesicles. This assay has been validated measuring Fluorescent…
CCR2 Chemokine Receptor Internalization Assay from Innoprot allows to assay compounds, or analyze their capability to modulate CCR2 receptor activation and the following redistribution process inside the cells. When a ligand binds to the CCR2, it activates a G protein, which internalizes in big and high intensity vesicles. This assay has been validated measuring Fluorescent…
CCK1 Cholecystokinin Receptor Assay from Innoprot allows to assay compounds, or analyze their capability to modulate CCKAR. When a ligand binds to the CCKAR, it activates a G protein; which in turn, triggers a cellular response mediated by calcium. The binding of CCK to CCKAR induces mobilization of intracellular calcium and activation of PKC via…
Calcitonin Receptor Assay from Innoprot allows to assay compounds, or analyze their capability to modulate CALCR. When a ligand binds to the CALCR, it activates a G protein, which in turn, triggers a cellular response mediated by both Calcium and cAMP. Our CALCR assay has been validated measuring both, cAMP & Calcium concentration changes in…
B1 Bradykinin Receptor Internalization Assay from Innoprot allows to assay compounds, or analyze their capability to modulate BDKRB1 activation and the following redistribution process inside the cells. When a ligand binds to the BDKRB1, it activates a G protein, which internalizes in big and high intensity vesicles. This assay has been validated measuring Fluorescent BDKRB1…
Bradykinin Receptor B2 Assay from Innoprot provides the analysis of both signalling pathways involving GPCR activation; G protein by Calcium flux and β-arrestin recruitment using Nomad multiplex technology. The primary transduction mechanism involves Gq/G11 family transducers, so we measure Ca2+ flux in combination with β-arrestin recruitment in this assay. The bradykinin receptor family is a group…
BB2 Bombesin Receptor Assay from Innoprot allows the measurement of BB2 Bombesin receptor activation by Calcium concentration increase in the cytosol. BB2 Bombesin Receptor, a.k.a. gastrin-releasing peptide receptor (GRPR), is a G protein-coupled receptor whose endogenous ligand is gastrin releasing peptide (GRP). It appears in the pancreas and also in the stomach, adrenal cortex and…
Arginine Vasopressin 2 receptor belongs to the same subfamily of G-protein coupled receptors of AVPR1A, AVPR1B and OXT receptors. The activity of Arginine Vasopressin receptor 2 (AVPR2) mediated by Gs, stimulates an adenylate cyclase second messenger system. V2 Vasopressin Receptor Assay from Innoprot allows the measurement of AVPR2 receptor activation using Nomad biosensors technology. V2…
Arginine Vasopressin 1A receptor belongs to the same subfamily of G-protein coupled receptors of AVPR1B, V2R and OTR receptors. The activity of Arginine Vasopressin receptor 1A (AVPR1A) mediated by Gq/G11, stimulates a phosphatidylinositol-calcium second messenger system. V1A Vasopressin Receptor Assay from Innoprot allows the measurement of AVPR1A receptor activation by Calcium concentration increase in the…