D5 Dopamine Receptor Assay from Innoprot allows the measurement of DRD5 receptor activation by cAMP increase in cell cytosol. We assay test-compounds analyzing the G-Protein signalling pathway by Gs involving DRD5 receptor activation. When an agonist binds to DRD5, it activates the Gs protein which; in turn, triggers a cellular response mediated by cAMP via…
D3 Dopamine Receptor Internalization Assay from Innoprot allows to assay compounds, or analyze their capability to modulate DRD3 receptor activation and the following redistribution process inside the cells. When a ligand binds to the DRD3, it activates a G protein, which internalizes in big and high intensity vesicles. This assay has been validated measuring Fluorescent…
D2 Dopamine Receptor Assay from Innoprot allows the measurement of DRD2 receptor activation by Adenylate cyclase inhibition. We assay test-compounds analyzing the G-Protein signalling pathway by Gi/o activation, which involves DRD2 receptor activation. When an agonist binds to DRD2, it activates the Gi/o protein which; in turn, triggers a cellular response mediated by cAMP via…
D1 Dopamine Receptor Assay from Innoprot allows the measurement of DRD1 receptor activation by cAMP increase in cell cytosol. We assay test-compounds analyzing the G-Protein signalling pathway by Gs involving DRD1 receptor activation. When an agonist binds to DRD1, it activates the Gs protein which; in turn, triggers a cellular response mediated by cAMP via…