M5 Muscarinic Acetylcholine Receptor Assay (CHRM5) from Innoprot allows to assay compounds, or analyze their capability to modulate CHRM5. When a ligand binds to the CHRM5, it activates a G protein; which in turn, triggers a cellular response mediated by calcium. The binding of an agonist to CHRM5 induces mobilization of intracellular calcium and also…
M4 Muscarinic Acetylcholine Receptor Assay (CHRM4) from Innoprot measures CHRM4 receptor activation using Nomad Biosensors technology. CHRM4 signaling occurs via adenylate cyclase inhibition through trimeric Gi/o proteins, reducing cAMP via PKA activation. In this assay, we measure the receptor activation/inhibition by PKA activation using Nomad Biosensors technology. The high reproducibility of this assay allows monitoring…
M3 Muscarinic Acetylcholine Receptor Assay (CHRM3) from Innoprot allows to assay compounds, or analyze their capability to modulate CHRM3. When a ligand binds to the CHRM3, it activates a G protein; which in turn, triggers a cellular response mediated by calcium. The binding of an agonist to CHRM3 induces mobilization of intracellular calcium and also…
M1 Muscarinic Acetylcholine Receptor Assay (CHRM1) from Innoprot allows to assay compounds, or analyze their capability to modulate CHRM1. When a ligand binds to the CHRM1, it activates a G protein; which in turn, triggers a cellular response mediated by calcium. The binding of an agonist to CHRM1 induces mobilization of intracellular calcium and also…