The beta-3 adrenergic receptor (β3 adrenoceptor); also known as ADRB3, is a cell membrane-spanning beta-adrenergic receptor. beta3 adrenoceptor Assay (ADRB3) from Innoprot allows the measurement of ADRB3 receptor activation using Nomad biosensors technology. beta3 Adrenoceptor signaling occurs via adenylate cyclase stimulation through trimeric Gs protein, increasing cAMP, and downstream L-type calcium channel interaction. cAMP-Nomad Biosensor…
The beta-2 adrenergic receptor (β2 adrenoceptor); also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor. beta2 adrenoceptor Assay (ADRB2) from Innoprot allows the measurement of ADRB2 receptor activation using Nomad biosensors technology. beta2 Adrenoceptor signaling occurs via adenylate cyclase stimulation through trimeric Gs proteins, increasing cAMP, and downstream L-type calcium channel interaction. cAMP-Nomad Biosensor…
ADORA2A gene encodes a protein which is one of receptor subtypes for adenosine, abundant in basal ganglia or vasculature. Activation of the adenosine A2A receptor by an agonist causes binding of Gs protein. Binding of Gs causes an adenylate cyclase stimulation and, therefore, an increase in the cAMP concentration. Adenosine A2A Receptor Assay from Innoprot…
ADORA2B gene encodes a protein which is one of receptor subtypes for adenosine, abundant in large intestine and bladder. A2B receptors plays an important role in mast cell activation, asthma, vasodilation, regulation of cell growth and intestinal function. Activation of the adenosine A2B receptor by an agonist causes binding of Gs protein. Binding of Gs…
The adenosine A3 receptor (ADORA3) is one member of the adenosine receptor group of GPCRs with adenosine as endogenous ligand. Activation of the adenosine A3 receptor by an agonist causes binding of Gi1/2/3 or Go protein. Binding of Gi1/2/3 causes an inhibition of adenylate cyclase and, therefore, a decrease in the cAMP concentration. Adenosine A3 Receptor…
The adenosine A1 receptor (ADORA1) is one member of the adenosine receptor group of GPCRs with adenosine as endogenous ligand. Activation of the adenosine A1 receptor by an agonist causes binding of Gi1/2/3 or Go protein. Binding of Gi1/2/3 causes an inhibition of adenylate cyclase and, therefore, a decrease in the cAMP concentration. Adenosine A1 Receptor…
NK2 Tachykinin Receptor Assay from Innoprot provides the analysis of both G-Protein signalling pathways involving GPCR activation; Calcium flux and cAMP flux using Nomad multiplex technology. The primary transduction mechanisms involve Gq/G11 and Gs family transducers, so we measure Ca2+ flux in combination with cAMP flux in this assay.. The tachykinin receptor NK2 (TACR2) also…
Histamine H1 Receptor Assay from Innoprot provides the analysis of both signalling pathways involving GPCR activation; G protein by Calcium flux and β-arrestin recruitment using Nomad multiplex technology. The primary transduction mechanism involves Gq/G11 family transducers, so we measure Ca2+ flux in combination with β-arrestin recruitment in this assay. Histamine 1 Receptor stimulation leads to the…
alpha1A Adrenoceptor assay (ADRA1A) from Innoprot provides the analysis of both signalling pathways involving receptor activation; G protein by Calcium flux and β-arrestin recruitment using Nomad multiplex technology. The alpha-1A adrenergic receptor (α1A adrenoreceptor), also known as ADRA1A, is member of Alpha-1-adrenergic receptors (alpha-1-ARs) family. They activate mitogenic responses and regulate growth and proliferation of…