alpha1B adrenoreceptor assay

alpha1B adrenoceptor assay

alpha1B Adrenoceptor assay (ADRA1B) from Innoprot provides the analysis of both signalling pathways involving receptor activation; G protein by Calcium flux and β-arrestin recruitment using Nomad multiplex technology. The alpha-1B adrenergic receptor (α1B adrenoceptor), also known as ADRA1B, is member of Alpha-1-adrenergic receptors (alpha-1-ARs) family. They activate mitogenic responses and regulate growth and proliferation of…

Cholecystokinin CCK2 receptor assay

Cholecystokinin CCK2 receptor assay

CCK2R (CCKBR) Human Cholecystokinin receptor assay from Innoprot provides the analysis of both signalling pathways involving GPCR activation; G protein by Calcium flux and β-arrestin recruitment using Nomad multiplex technology. The cholecystokinin B receptor (CCKBR, CCK2R) is a protein that in humans is encoded by the CCKBR gene. This gene encodes a G-protein-coupled receptor for…

Neurotensin Receptor 1 Assay

Neurotensin Receptor 1 Assay

Human Neurotensin receptor 1 assay (NTSR1) from Innoprot provides the analysis of both signalling pathways involving GPCR activation; G protein by Calcium flux and β-arrestin recruitment using Nomad multiplex technology. The primary transduction mechanism involves Gq/G11 family transducers, so we measure Ca2+ flux in combination with β-arrestin recruitment in this assay. Neurotensin receptor 1 belongs to…

PAR2 Functional Assay

PAR2 Receptor Assay

Proteinase-activated Receptor 2 – PAR2 Receptor Assay from Innoprot provides the analysis of both signalling pathways involving GPCR activation; G protein by Calcium flux and β-arrestin recruitment using Nomad multiplex technology. The primary transduction mechanism involves Gq/G11 family transducers, so we measure Ca2+ flux in combination with β-arrestin recruitment in this assay. Protease activated receptor 2…

Androgen Receptor Translocation Assay

Androgen Receptor Translocation Assay

Androgen Receptor Translocation Assay from Innoprot analyzes stimuli for their ability to modulate receptor nuclear translocation process. To perform this assay, we quantify the fluorescence distribution inside the cells with a High Content Imaging system. Human androgen receptor (hAR) is a ligand-dependent transcription factor responsible for the development of the male phenotype. The androgen receptor…

Thyrotropin-releasing Hormone Receptor Assay

Thyrotropin-releasing Hormone Receptor Assay

Thyrotropin-releasing hormone (TRH), also called thyrotropin-releasing factor (TRF) or thyroliberin, is one of the smallest hormones. It is a releasing hormone produced by the hypothalamus, that stimulates the release of TSH and prolactin. It is a tropic, tripeptidal hormone which consists of a miniature chain of just three amino acid building blocks. Secretion of thyrotropin-releasing hormone…

TSH Functional Assay

TSH Functional Assay

Thyroid-stimulating hormone (also known as thyrotropin, thyrotropic hormone or TSH) is a pituitary hormone that stimulates the thyroid gland. Pituitary gland produces and releases TSH into the bloodstream. It controls production of the thyroid hormones, thyroxine and triiodothyronine, by the thyroid gland by binding to receptors located on cells in the thyroid gland. Thyroxine and…

CB1 Cannabinoid Receptor Assay

CB1 Cannabinoid Receptor Assay

Human CB1 cannabinoid receptor assay (CNR1) from Innoprot provides the analysis of both signalling pathways involving GPCR activation; G Protein by the analysis of Gi/Go activation and β-arrestin recruitment using Nomad multiplex technology. When an agonist binds to CNR1, it activates Gi/Go, which in turn, triggers a cellular response involving PKA activation. In this assay…

Glucocorticoid Receptor Translocation Assay

Glucocorticoid Receptor Translocation Assay

Glucocorticoid Receptor Translocation Assay from Innoprot analyzes stimuli for their ability to modulate receptor nuclear translocation process. To perform this assay, we quantify the fluorescence distribution inside the cells with a High Content Imaging system. Glucocorticoid receptors (GRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid, progesterone and androgen receptors. They…