publication

Article Published: Design, synthesis and biological characterization of novel activators of the TrkB neurotrophin receptor

Sin categoría

Numerous studies have been published about the implication of the neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor TrkB in the pathogenesis of several neurodegenerative conditions such as Alzheimer’s disease, Parkinson’s disease, Multiple Sclerosis and motor neuron disease. BDNF activates the TrkB receptor with high potency and specificity, promoting neuronal survival, differentiation and synaptic plasticity.…

Biomedicine and Pharmacotherapy

Synthesis, characterization, theoretical studies and biological (antioxidant, anticancer, toxicity and neuroprotective) determinations of a copper(II) complex with 5-hydroxytryptophan

Sin categoría

5-Hydroxy-L-tryptophan (5-HTP) is a serotonin pathway metabolite of L-tryptophan in the brain. In the knowledge that the biological properties of some compounds can be modified upon metal complexation, a new solid metal complex, [Cu(5-hydroxytryptophan)2].H2O (Cu5HTP), has been synthesized and characterized to analyze the modification of some biological properties. The conformational investigations (optimized in gas phase…

What’s New At Innoprot – GPCR Nomad Cell Lines

Sin categoría

A novel family of GPCR cell lines have been developed through stable transfection with different fluorescent Nomad reporter genes to monitor b-arrestin recruitment in combination with Ca++ increase measurement, allowing a multiplex funcitonal assay to characterize GPCR activation pathways and identify directly GPCR biased ligands. Each cell line is stably transfected with a label-free GPCR,…

SLAS Technology

Nomad Biosensors: A New Multiplexed Technology for the Screening of GPCR Ligands

Sin categoría

Nomad Technology (Innoprot [Innovative Technologies in Biological Systems], Derio, Spain), a novel tool for multiplexing high-throughput cell-based G protein-coupled receptor (GPCR) assays, is described in this work. This new technology comprises a family of fluorescent biosensors called Nomad Biosensors that allow for the measurement of responses mediated by G proteins through their interactions with second-messenger…

PLOS Neglected Tropical Diseases

Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease

Sin categoría

Chagas disease remains one of the most neglected diseases in the world despite being the most important parasitic disease in Latin America. The characteristic chronic manifestation of chagasic cardiomyopathy is the region’s leading cause of heart-related illness, causing significant mortality and morbidity. Due to the limited available therapeutic options, new drugs are urgently needed to…

photo-BioEurope

Meet us at the International Partnering Conference Bio-Europe

Sin categoría

Innoprot will be attending the 23rd Annual International Partnering Conference BIO-EUROPE to be held in Berlin, Germany, 6-8 November 2017.  Jorge Gamiz – Business Development Director, will be available to meet during the Conference to discuss the company’s capabilities, strategic partnership and collaboration interests. According to BIO-Europe, last year’s Conference hosted 20,833 on-to-one meeting among…