cAMPNOMAD ADRB3 Receptor Cell Line

The beta-3 adrenergic receptor (β3 adrenoceptor); also known as ADRB3, is a cell membrane-spanning beta-adrenergic receptor. beta3 adrenoceptor Assay (ADRB3) from Innoprot allows the measurement of ADRB3 receptor activation using Nomad biosensors technology. beta3 Adrenoceptor signaling occurs via adenylate cyclase stimulation through trimeric Gs protein, increasing cAMP, and downstream L-type calcium channel interaction. cAMP-Nomad Biosensor measures the receptor activation by cAMP accumulation.

Cell line used: ADRB3 Nomad Cell Line

Readout: cAMP Flux

Agonist: Isoproterenol

EC50 Agonist: 2.64 x 10-11 M for cAMP Flux

Type of Assay: Cell-based / Functional

Detection Method: Fluorimetry

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