Project granted by the Ministry of Science and Innovation to develop biotechnology tools to speed up drug discovery againts COVID-19

The project “Generation of biotechnology tools to speed up the drug repurposing process against COVID-19” has been granted by the Ministry of Science and Innovation of the Government of Spain confinancing with ERDF (European Regional Development Fund). The aim of the project is to generate cell lines stably expressing the proteins necessary for SARS-CoV-2 cell…

Innoprot ha sido confinanciada en una acción conjunta del Gobierno Vasco y la Unión Europea a través del Fondo Europeo de Desarrollo Regional 2014-2020 (FEDER)

Innoprot ha sido confinanciada en una acción conjunta del Gobierno Vasco y la Unión Europea a través del Fondo Europeo de Desarrollo Regional 2014-2020 (FEDER). El proyecto financiado ha sigo el TKRscreen, para el Desarrollo de Biosensores Celulares Fluorescentes que permiten Monitorizar la Fosforilación de Receptores Tirosin Kinasa y su relación con receptores GPCRs.

Scientific Reports

Article published: Assessing the role of surface glycans of extracellular vesicles on cellular uptake

Extracellular vesicles (EVs) are important mediators of cell-cell communication in a broad variety of physiological contexts. However, there is ambiguity around the fundamental mechanisms by which these effects are transduced, particularly in relation to their uptake by recipient cells. Multiple modes of cellular entry have been suggested and we have further explored the role of…

Experimental Eye Research

Article published: Effect of somatostatin on human retinal pigment epithelial cells permeability

PURPOSE: To assess the effect of somatostatin (SST) on the permeability of human retinal pigment epithelial cells. METHODS: We conducted two experiments, exposing cells from human-fetal retinal pigment epithelium (hfRPE) cultures to vascular endothelial growth factor (VEGF), with or without SST pretreatment, in one, and to hypoxic conditions, again with or without SST pretreatment, in…

Physiological Reports

Article published: Rescue of degenerating neurons and cells by stem cell released molecules: using a physiological renormalization strategy

Evidence suggests that adult stem cell types and progenitor cells act collectively in a given tissue to maintain and heal organs, such as muscle, through a release of a multitude of molecules packaged into exosomes from the different cell types. Using this principle for the development of bioinspired therapeutics that induces homeostatic renormalization, here we…