Proteinase-activated Receptor 2 – PAR2 Receptor Assay from Innoprot provides the analysis of both signalling pathways involving GPCR activation; G protein by Calcium flux and β-arrestin recruitment using Nomad multiplex technology. The primary transduction mechanism involves Gq/G11 family transducers, so we measure Ca2+ flux in combination with β-arrestin recruitment in this assay.
Protease activated receptor 2 (PAR2) is member of the protease-activated receptor family. Other names for this receptor are coagulation factor II (thrombin) receptor-like 1 (F2RL1) and G-protein coupled receptor 11 (GPR11). PAR2 modulates inflammatory responses, obesity, metabolism, and acts as a sensor for proteolytic enzymes generated during infection.
Receptor Information: PAR2 Receptor
Assay: GPCR, Proteinase-activated receptors
Area: CNS, Diabetes, Inflammation