The beta-2 adrenergic receptor (β2 adrenoreceptor); also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor. It interacts with (binds) epinephrine; a hormone and neurotransmitter (ligand synonym, adrenaline) whose signaling, via adenylate cyclase stimulation through trimeric Gs proteins, increased cAMP, and downstream L-type calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation. cAMP-Nomad beta-2 adrenergic receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as isoproterenol.
Red Fluorescent cAMP Nomad Biosensor also expressed in the cell line, allows monitoring cAMP concentration changes when receptor is activated/inhibited.
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