cAMPNOMAD D5 Dopamine Receptor Cell Line

Reference: P70509

cAMPNOMAD D5 Dopamine Receptor Cell Line

cAMPNOMAD Cells are cell lines stably co-expressing tag-free GPCRs and cAMP Nomad Biosensor to monitor G-protein modulation by cAMP release. Each vial of cAMPNOMAD D5 Dopamine Receptor Cell Line contains U2OS cells stably expressing the following constructs:

  • human D5 Dopamine Receptor (DRD5) with no tag
  • cAMP Nomad Biosensor (Red Fluorescence)

cAMPNOMAD DRD5 Cell Line allows to assay compounds analyzing the G-Protein signalling pathway by Gs involving receptor activation. When an agonist binds to DRD5, the Gs protein is activated which, in turn, triggers a cellular response mediated by cAMP via adenylate cyclase stimulation. This leads to an increase of red fluorescence intensity of cAMP biosensor. So, the activity can be easily quantified on living cells in a dose-response manner by fluorescence emission in a microplate reader.

Size/Quantity: 2 vials containing 3×106 cells / vial


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Dopamine receptors play important roles in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control; as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function occurs in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets. The D1 and D5 receptors have a high degree of structural homology and few ligands are available that can distinguish between them as yet; however there are a number of ligands that are selective for D1/5 over the other dopamine receptors. The recent development of a selective D5 antagonist has allowed the action of D1-mediated responses to be studied in the absence of a D5 component, but no selective D5 agonists are yet available. cAMPNOMAD D5 Dopamine Receptor Cell Line allows the measurement of the activity of ligands, such as Dopamine.

Click HERE to know more about DRD5 Receptor.


  • Reference: P70509
  • Nomad Biosensors: cAMP
  • GeneBank Accesion Number: NC_000004.12
  • Size/Quantity: 2 vials containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice