The activity of AVPR2 Receptor is mediated by G proteins which stimulate Adenylate cyclase – cAMP second messenger system. The AVPR2 receptor belongs to the same subfamily of G-protein coupled receptors of AVPR1A, AVPR1B and OTR receptors. AVPR2 is pressent in the kidney tubule, predominantly in the membrane of cells of the distal convoluted tubule and collecting ducts. AVPR2 is also present outside the kidney in vascular endothelium. Stimulation causes the release of von Willebrand factor and factor VIII from the endothelial cells. This is useful in the treatment of hemophilia A as well as Von Willebrand disease. cAMPNOMAD AVPR2 Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as [Arg8]‐AVP.
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