The bradykinin receptor family is a group of G-protein receptors whose principal ligand is the protein bradykinin. This gene encodes a receptor for bradykinin B1. Bradykinin, a 9 aa peptide, appears mainly in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Classical agonist of this receptor includes bradykinin1-8 (bradykinin with the first 8 amino acid) and antagonist includes [Leu8]-bradykinin1-8. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Green Fluorescent B1 Bradykinin Receptor from Innoprot allows the measurement of the activity and potency of ligands; such as bradykinin.
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