The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two cannabinoid receptors play and important role in the cannabinoid-induced CNS effects, including alterations in mood and cognition. Changes in endocannabinoid levels and/or CB2 receptor expressions are present in almost all diseases affecting humans; such as cardiovascular, gastrointestinal, liver, kidney, neurodegenerative, psychiatric, bone, skin, autoimmune, lung disorders or pain and cancer. The prevalence of this trend suggests that modulating CB2 receptor activity by either selective CB2 receptor agonists or inverse agonists/antagonists depending on the disease and its progression holds unique therapeutic potential for these pathologies. Green Fluorescent CB2 Cannabinoid Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as CP55940.
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