This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1 (CCL2), a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 plays an important role in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. An excessive monocytes infiltration generates higher inflammation and increases the risk of heart failure. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. Green Fluorescent CCR2 Chemokine Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as MCP-1.
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