DRD3 encodes the D3 subtype of the dopamine receptor. The D3 subtype inhibits adenylyl cyclase through inhibitory G-proteins. This receptor is present in phylogenetically older regions of the brain, suggesting that this receptor plays a role in cognitive and emotional functions. It is a target for drugs which treat schizophrenia, drug addiction, and Parkinson’s disease. Alternative splicing of this gene results in multiple transcript variants that would encode different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). D3 agonists such as 7-OH-DPAT, pramipexole, and rotigotine, among others, display antidepressant effects in rodent models of depression. DRD3 antagonism has been shown to exacerbate locomotor activity in the brain. Green Fluorescent D3 Dopamine Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as Dopamine.
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