Green Fluorescent D5 Dopamine Receptor Cell Line

Reference: P30222

Green Fluorescent D5 Dopamine Receptor Cell Line

Green Fluorescent GPCR cell lines from Innoprot allows to perform GPCR internalization assays. Each vial of Green Fluorescent D5 Dopamine Receptor Cell Line contains SH-SY5Y cells stably expressing DRD5 Receptor tagged with tGFP. These Cell lines proliferate in vitro maintaining fluorescent GPCR expression following the cell culture manual.

Innoprot Green Fluorescent D5 Dopamine Receptor Cell Line allows to assay compounds, or analyze their capability to modulate DRD5 Receptor activation and the following redistribution process inside the cells. When a ligand binds to the DRD5 Receptor, it activates a G protein, which internalizes in big and high intensity vesicles. This cell line has been validated measuring Fluorescent D5 Dopamine Receptor redistribution by increase of fluorescence surrounding the nuclei using image analysis algorithms. The high reproducibility of this assay allows monitoring DRD5 Receptor redistribution process in High Throughput Screening.


Size/Quantity: 2 vials containing 3×106 cells / vial


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Dopamine receptors play important roles in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control; as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function occurs in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets. The D1 and D5 receptors have a high degree of structural homology and few ligands are available that can distinguish between them as yet; however there are a number of ligands that are selective for D1/5 over the other dopamine receptors. The recent development of a selective D5 antagonist has allowed the action of D1-mediated responses to be studied in the absence of a D5 component, but no selective D5 agonists are yet available. Green Fluorescent D5 Dopamine Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as Dopamine.

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  • Reference: P30222
  • DNA Accession Number: BC009748
  • Size/Quantity: 2 vials containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice