Mu, delta and kappa opioid receptors are GPCRs, which play a central role in pain control. They are key players in hedonic homeostasis, mood and well-being. The three receptors and their endogenous opioid peptides also regulate responses to stress, and a number of peripheral physiological functions including respiratory, gastrointestinal, endocrine and immune processes. The κ-opioid receptor (KOR) causing effects related to nociception, consciousness, motor control, and mood. Dysregulation of this receptor system plays an important role in alcohol and drug addiction. The KOR may provide a natural addiction control mechanism, and therefore, drugs that target this receptor may have therapeutic potential in the treatment of addiction. Fluorescent Kappa Opioid Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as Dynorphin.
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