The muscarinic acetylcholine receptor family consists of five GPCRs that mediate some of the neurotransmission functions of acetylcholine in the CNS and the periphery. The M1 receptor, along with the M3 and M5 receptors; signal through Gq/11 and subsequent release of Calcium from the ER. The M1 receptor mediates depolarization of ganglia by inhibition of voltage-gated M-type K+ channels. In addition, the M1 receptor mediates venous contraction. The muscarinic cholinergic receptor 1 plays an important role in mediation of vagally-induced bronchoconstriction, but also in the acid secretion of the gastrointestinal tract. Green Fluorescent M1 Muscarinic Acetylcholine Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as oxotremorine.
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