Green Fluorescent NK1 Tachykinin Receptor Cell Line

Reference: P30229

Green Fluorescent NK1 Tachykinin Receptor Cell Line

Green Fluorescent GPCR cell lines from Innoprot allows to perform GPCR internalization assays. Each vial of Green Fluorescent NK1 Tachykinin Receptor Cell Line contains SH-SY5Y cells stably expressing NK1 Receptor tagged with tGFP. These Cell lines proliferate in vitro maintaining fluorescent GPCR expression following the cell culture manual.

Innoprot Green Fluorescent NK1 Tachykinin Receptor Cell Line allows to assay compounds, or analyze their capability to modulate NK1 Receptor activation and the following redistribution process inside the cells. When a ligand binds to the NK1 Receptor, it activates a G protein, which internalizes in big and high intensity vesicles. This cell line has been validated measuring Fluorescent NK1 Receptor redistribution by increase of fluorescence surrounding the nuclei using image analysis algorithms. The high reproducibility of this assay allows monitoring NK1 Receptor redistribution process in High Throughput Screening.

 

Size/Quantity: 2 vials containing 3×106 cells / vial

6.950,00

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The tachykinin receptor NK1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene. The NK1 receptor is present in both the central and peripheral nervous system. This receptor is an attractive drug target, particularly with regards to potential analgesics and anti-depressants. It is also a potential treatment for alcoholism and opioid addiction. In addition, it is a candidate in the etiology of bipolar disorder. Finally NK1R antagonists may also have a role as novel antiemetics and hypnotics. Green Fluorescent NK1 Tachykinin Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as Substance P.

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  • Reference: P30229
  • DNA Accession Number: AY462098
  • Size/Quantity: 2 vials containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice