Green Fluorescent SST2 Somatostatin Receptor Cell Line

Reference: P30265

Green Fluorescent SST2 Somatostatin Receptor Cell Line

Green Fluorescent GPCR cell lines from Innoprot allows to perform GPCR internalization assays. Each vial of Green Fluorescent SST2 Somatostatin Receptor Cell Line contains U2OS cells stably expressing SST2R tagged with tGFP. These Cell lines proliferate in vitro maintaining fluorescent GPCR expression following the cell culture manual.

Innoprot Green Fluorescent SST2 Somatostatin Receptor Cell Line allows to assay compounds, or analyze their capability to modulate SST2R activation and the following redistribution process inside the cells. When a ligand binds to the SST2 Receptor, it activates a G protein, which internalizes in big and high intensity vesicles. This cell line has been validated measuring Fluorescent SST2R redistribution by increase of fluorescence surrounding the nuclei using image analysis algorithms. The high reproducibility of this assay allows monitoring SST2 Receptor redistribution process in High Throughput Screening.

 

Size/Quantity: 2 vials containing 3×106 cells / vial

6.950,00

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The somatostatin receptor 2 (SSTR2), which belongs to the GPCR family, is a protein which is present in the pancreas, but also in other tissues; such as the cerebrum and kidney and in lower amount in the jejunum, colon and liver. In the pancreas, after binding to somatostatin, it inhibits the secretion of pancreatic enzymes. During development, it stimulates neuronal migration and axon outgrowth. SSTR2 also has the ability to stimulate apoptosis in many cells including cancer cells, converting it in a possible target in cancer treatment for its ability to inhibit tumor growth. Green Fluorescent SST2 Somatostatin Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as SST.

Click HERE to know more about SST2 Receptor.

  • Reference: P30265
  • DNA Accession Number: AY236542
  • Size/Quantity: 2 vials containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice