Green Fluorescent SST3 Somatostatin Receptor Cell Line

Reference: P30266

Green Fluorescent SST3 Somatostatin Receptor Cell Line

Green Fluorescent GPCR cell lines from Innoprot allows to perform GPCR internalization assays. Each vial of Green Fluorescent SST3 Somatostatin Receptor Cell Line contains U2OS cells stably expressing SST3R tagged with tGFP. These Cell lines proliferate in vitro maintaining fluorescent GPCR expression following the cell culture manual.

Innoprot Green Fluorescent SST3 Somatostatin Receptor Cell Line allows to assay compounds, or analyze their capability to modulate SST3R activation and the following redistribution process inside the cells. When a ligand binds to the SST3 Receptor, it activates a G protein, which internalizes in big and high intensity vesicles. This cell line has been validated measuring Fluorescent SST3R redistribution by increase of fluorescence surrounding the nuclei using image analysis algorithms. The high reproducibility of this assay allows monitoring SST3 Receptor redistribution process in High Throughput Screening.

 

Size/Quantity: 2 vials containing 3×106 cells / vial

6.950,00

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SSTR3 encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. SSTR3 is present in highest levels in brain and pancreatic islets. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other GPCRs. Green Fluorescent SST3 Somatostatin Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as SST.

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  • Reference: P30266
  • DNA Accession Number: AY322541
  • Size/Quantity: 2 vials containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice