Innoprot offers a novel family of cell lines through stable transfection with different fluorescent isoforms of tau protein and mutants. Each Green fluorescent tau SH-SY5Y cell line is stably‐transfected and it is ready to use in cell‐based assay applications. These stably transfected cell lines provide consistent levels of expression, which helps to simplify the interpretation of the results. These cell lines are valuable tools to use as “in vitro” models for research studies.
Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD), the neurofibrillary tangles; and is therefore of major interest as an indicator of disease mechanisms. They are abundant in neurons of the central nervous system and are less common elsewhere; but also appears at very low levels in CNS astrocytes and oligodendrocytes. They accumulate in neurofibrillary tangles in Alzheimer’s disease (AD) brain. There is significant evidence that a disruption of normal phosphorylation events results in tau dysfunction. It is a contributing factor to the pathogenic processes of neurodegenerative diseases, such as AD.
