Prostaglandin receptors or prostanoid receptors represent a sub-class of cell surface membrane receptors. Prostaglandins are a group of lipid compounds that participate in a wide range of body functions. EP2 Prostanoid Receptor, which belongs to the G protein-coupled receptor familiy, is one of four receptors which bind with and mediate cellular responses principally to prostaglandin E2) (PGE2). EP2 Receptor generally binds to PGE2 with lesser affinity and responsiveness to certain other prostanoids. This receptor is present in several tissues, such as human small intestine, lung, media of arteries and arterioles of the kidney, thymus, uterus, brain cerebral cortex, brain striatum, brain hippocampus, corneal epithelium, corneal choriocapillaries, Myometriuml cells, eosinophiles, sclera of the eye, articular cartilage, the corpus cavernosum of the penis, and airway smooth muscle cells. HiTSeeker EP2 Prostanoid Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as PGE2.
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