HiTSeeker FP Prostanoid Receptor Cell Line

Reference: P30408

HiTSeeker FP Prostanoid Receptor Cell Line

HiTSeeker are cell lines stably expressing label-free GPCRs, also known as seven-(pass)-transmembrane domain receptors. Each vial of HiTSeeker FP Prostanoid Receptor Cell Line contains U2OS cells stably expressing FP Receptor with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual.

Innoprot HiTSeeker FP Prostanoid Receptor Cell Line allows to assay compounds, or analyze their capability to modulate FP receptor. When a ligand binds to the FPR, it activates a G protein, which in turn, triggers a cellular response mediated by calcium. HiTSeeker FP Receptor cell line has been validated measuring calcium concentration changes in the cytosol upon activation with PGE2. The high reproducibility of this assay allows monitoring FP Receptor activation process in High Throughput Screening.

Size/Quantity: 2 vials containing 3×106 cells / vial

5.250,00

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Prostaglandin F receptor (FP) is a receptor belonging to the prostaglandin (PG) group of receptors. FP binds to and mediates the biological actions of Prostaglandin F2α (PGF2α). In humans, FP mRNA and/or protein is highly present in the uterine myometrium; throughout the eye and ovarian. FP receptor agonists, such as latanoprost, travoprost or bimatoprost, are drugs to treat glaucoma and other causes of intra-ocular hypertension. The FP receptor agonist, bimatoprost, in the form of an 0.03% ophthalmic solution termed Latisse, is an approved drug to treat hypotrichosis of the eyelashes; in particular to darken and lengthen eyelashes for cosmetic purposes. HiTSeeker FP Prostanoid Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as PGF2α.

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  • Reference: P30408
  • Size/Quantity: 2 vials containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice