HiTSeeker Urotensin Receptor Cell Line

Reference: P30424

HiTSeeker Urotensin Receptor Cell Line

HiTSeeker are cell lines stably expressing label-free GPCRs, also known as seven-(pass)-transmembrane domain receptors. Each vial of HiTSeeker Urotensin Receptor Cell Line contains U2OS cells stably expressing Urotensin Receptor (aka GPR14 or UTS2R) with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual.

Innoprot HiTSeeker Urotensin Receptor Cell Line allows to assay compounds, or analyze their capability to modulate UT Receptor. When a ligand binds to the UT Receptor, it activates a G protein, which in turn, triggers a cellular response mediated by calcium. HiTSeeker Urotensin Receptor cell line has been validated measuring calcium concentration changes in the cytosol upon activation with UT-II. The high reproducibility of this assay allows monitoring UT Receptor activation process in High Throughput Screening.

Size/Quantity: 2 vials containing 3×106 cells / vial


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The urotensin-2 receptor, also known GPR14 is a class A rhodopsin family GPCR that is 386 amino acids long. It binds primarily to the neuropeptide urotensin II. UT receptor is present in the myocardium, and smooth muscle cells and endothelial cells of arteries and veins. Expression levels of UT receptor mRNA are high in the atrium of rats with congestive heart failure resulting from coronary artery ligation, but also in the atrium, ventricle, and aorta of Spontaneously Hypertensive Rats. In the kidney, UT receptor is present in the renal tubular cells and vascular endothelial cells. Functions of the urotensin II receptor may play roles in cardiomyocitic hypertrophy, stress, and REM sleep. HiTSeeker Urotensin Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as UT-2.

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  • Reference: P30424
  • Size/Quantity: 2 vials containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice