Human Hepatic Sinusoidal Endothelial Cells

Reference: P10652

Human Hepatic Sinusoidal Endothelial Cells

Human Hepatic Sinusoidal Endothelial Cells (HHSEC) provided by Innoprot are isolated from human healthy liver. HHSEC are cryopreserved at passage one and delivered frozen. Each vial of Human Hepatic Sinusoidal Endothelial Cells contains more than 500.000 viable cells. They are guaranteed to further expand for 15 population doublings following the instructions provided in the technical sheet.

Innoprot also offers optimized medium and reagents for the growth of Human Hepatic Sinusoidal Endothelial Cells which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro HHSEC culture.

 

Size/Quantity: 500.000 Cells / vial

795,00

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Endothelial cells perform multiple physiological functions and are central to many pathological processes. The liver contains two distinct endothelial cell types: vascular and sinusoidal (SEC). Human Hepatic Sinusoidal endothelial cells are microvascular endothelial cells with a unique phenotype reminiscent of dendritic cells; but also with a unique function as antigen-presenting cells for CD4+ T cells. Thus, SEC represent a new type of organ-resident “non-professional” antigen-presenting cell that appears to play an important role in the local control of the immune response and the induction of immune tolerance in the liver. The hepatic microenvironment tightly control antigen presentation by SEC to avoid immune-mediated damage. SEC express well-characterized surface receptors and differ morphologically and metabolically from large-vessel endothelia. Previous studies have shown that SEC are dynamic regulators of porosity that respond rapidly and locally to environmental zonal stimuli during liver regeneration.

  • Reference: P10652
  • Size/Quantity: 5x105 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice