Immortalized Human Bronchial Epithelial Cell Line

Reference: P10557-IM

Immortalized Human Bronchial Epithelial Cell Line

Immortalized Human Bronchial Epithelial Cell Line (IM-HBEpiC) provided by Innoprot have been developed by immortalizing primary human bronchial epithelial cells with SV40 Large T antigen.

Immortalized cells were controlled passaging side by side with the primary cells. Primary cells go into senescence after the 3th passage while the SV40‐tranduced cells go beyond 30 passages.

Each vial of IM-HBEpiC contains more than 1 million viable cells. Innoprot also offers optimized medium and reagents for the growth of IM-HBEpC which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro IM-HBEpiC culture.

 

Size/Quantity: 1 million cells / vial

1.950,00

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The respiratory epithelium comprises a mixed population of ciliated, nonciliated, and mucous-secreting cells from proximal to distal airways. The individual characteristics of these cells create not only an effective physical barrier against various noxious substances, but also a highly sophisticated host defense system by producing and releasing a large number of chemical mediators and cytokines. The bronchial epithelium consists of both, the surface epithelial cells and mucus glands. The surface epithelial cells comprise three principle cell types; basal, goblet, and ciliated cells, of which the latter two form a suprabasal columnar structure. They are necessary for mucociliary clearance.

Studies using human bronchial epithelial cells (BEpiC) have demonstrated that IL-4 and IL-13 stimulation can modify cellular proliferation, but also ciliary beating, and mucous production. Bronchial epithelial cell proliferation depends in part by EGF receptor signaling. They are also useful tools to understand the highly integrated balance between bronchial epithelial proliferation, differentiation, and cell death. Immortalized Human Bronchial Epithelial Cell Line also allow to stablish in vitro models for HIgh Throughput and High Content Screening.

  • Reference: P10557-IM
  • Size/Quantity: 1x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice