Immortalized Human Hepatic Sinusoidal Endothelial Cells

Reference: P10652-IM

Immortalized Human Hepatic Sinusoidal Endothelial Cells

Immortalized Human Hepatic Sinusoidal Endothelial Cells (IM-HHSEC) provided by Innoprot have been developed by immortalizing primary human hepatic sinusoidal endothelial cells with SV40 Large T antigen.

Immortalized cells were controlled passaging side by side with the primary cells. Primary cells go into senescence after the 3rd passage while the SV40‐tranduced cells go beyond 30 passages.

Each vial of IM-IM-HHSEC contains more than 1 million viable cells. Innoprot also offers optimized medium and reagents for the growth of IM-IM-HHSEC which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro IM-HHSEC culture.


Size/Quantity: 1 million cells / vial


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Endothelial cells perform multiple physiological functions and are central to many pathological processes. The liver contains two distinct endothelial cell types: vascular and sinusoidal (SEC). Human Hepatic Sinusoidal endothelial cells are microvascular endothelial cells with a unique phenotype reminiscent of dendritic cells; but also with a unique function as antigen-presenting cells for CD4+ T cells. Thus, SEC represent a new type of organ-resident “non-professional” antigen-presenting cell that appears to play an important role in the local control of the immune response and the induction of immune tolerance in the liver. The hepatic microenvironment tightly control antigen presentation by SEC to avoid immune-mediated damage. SEC express well-characterized surface receptors and differ morphologically and metabolically from large-vessel endothelia. Previous studies have shown that SEC are dynamic regulators of porosity that respond rapidly and locally to environmental zonal stimuli during liver regeneration.

Immortalized Human Hepatic Sinusoidal Endothelial Cells allow to stablish in vitro models for HIgh Throughput and High Content Screening.

  • Reference: P10652-IM
  • Size/Quantity: 1x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice