Mesenchymal stromal cells (MSCs) are heterogeneous group of cells with multipotent capability. Many reports suggest that MSCs reside in almost all tissues and organs. Pancreatic stem cells are of great clinical interest due to their potential role in treatment of diabetes mellitus (DM). Pancreatic Stromal Cells are also able to differentiate into pancreatic endocrine lineage cells. MSC transplantation has shown promising results in treatment of diseases such as diabetes, autoimmune diseases, brain repair, and blood malignancies.

Immortalized Human Pancreatic Stromal Cell Line is a useful tool to understand the highly integrated balance between proliferation, differentiation, and cell death. This cell line also allow to stablish in vitro models for HIgh Throughput and High Content Screening.