CCK receptors significantly influence neurotransmission in the brain, regulating anxiety, feeding, and locomotion. Two GPCRs known as CCK1 and CCK2 receptors composes the CCK receptors family. CCK2R gene encodes a G protein-coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. Cholecystokinin B receptor is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is present principally in the central nervous system and the gastrointestinal tract. CCK-B expression may correlate parallel to anxiety and depression phenotypes in humans. MPXNOMAD CCK2 Cholecystokinin Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as CCK.
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