The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors. Histamine H1 receptor is present in several tissues such as central nervous system, cardiovascular system, smooth muscles, or lymphocytes. In vascular endothelial cells, stimulation of histamine H1 receptors lead to the synthesis and release of several neurochemicals and neuromodulators; such as prostacyclin, platelet–activating factor, and nitric oxide (NO). In addition, stimulation of the H1 receptor causes changes in vascular permeability, particularly the postcapillary venule as a result of endothelial cell contraction. Antihistamines, which act on this receptor, are anti-allergy drugs. MPXNOMAD H1 Histamine Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as Histamine.
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